Research papers

glasses on scientific papers

2016

  • Witchel HJ, Santos CP, Ackah JK, Westling CEI, Chockalingam N (2016).  Non-Instrumental Movement Inhibition (NIMI) differentially suppresses head and thigh movements during screenic engagement: dependence on interaction. Frontiers in Psychology, 10.3389/fpsyg.2016.00157 Open paper in a new window. Note that this paper has supplementary data and a supplementary video (at the left of the Frontiers In Psychology page)

2015

  • Wilkes S, Wongsriruksa S, Howes, P, Gamester R, Witchel H, Conreen M, Laughlin Z and Miodownik M (2015). Design tools for interdisciplinary translation of material experiences. Materials and Design, 90: 1228-1237.  Download it here.

2014

  • Witchel HJ, Westling C, Tee J, Healy A, Needham R, Chockalingam N (2014). A time series feature to detect two types of boredom when motion capture is a surrogate for engagement in seated volunteers interacting with computer-based stimuli. ECCE 2014 Proceedings of the 32nd European Conference on Cognitive Ergonomics. Download it here
  • Witchel HJ, Westling CEI, Tee J, Healy A, Needham R, Chockalingam N (2014). What does not happen: Quantifying embodied engagement using NIMI and self-adaptors. Participations: Journal of Audience and Reception Studies. 11(1): 304-330. Download it here
  • Lopez-Mendez A, Westling CEI, Emonet R, Easteal M, Lavia L, Witchel HJ, Odobez J-M (2014). Automated bobbing and phase analysis to measure walking entrainment to music. International Conference on Image Processing. (Paris). Download it here
  • Easteal, M., Bannister, S., Kang, J., Aletta, F., Lavia, L., & Witchel, H. (2014). Urban Sound Planning in Brighton and Hove. In Forum Acusticum 2014. Polish Acoustical Society Krakow, Poland. Download it here
  • Howes PD, Wongsriruksa S, Laughlin Z, Witchel HJ and Miodownik M (2014).  The perception of materials through oral sensation. PLoS One, 9(8), e105035. Download it here

2013

  • Witchel HJ, Westling C, Needham R, Healy A, Chockalingam N (2013). Mean head and shoulder heights when seated: subconscious postural cycles during discrete, computerised stimuli. ECCE 2013 Proceedings of the 31st European Conference on Cognitive Ergonomics. Download it here
  • Westling CEI, Barker L, Healy A, Needham R, Witchel HJ, Chockalingam N (2013). Spatial Data Correlation: An interactive 3D visualisation tool for correlating the motion capture data streams from different devices. EVA 2013 – Electronic Visualisation in the Arts (London). Download it here
  • Witchel HJ, Westling CEI, (2013). Inputs and Outputs: Engagement in Digital Media from the Maker’s Perspective. Excursions Journal, 4(1). Download it here Or see it on the Excursions website
  • Witchel HJ (2013).  Engagement: the Inputs and the Outputs. Proceedings of Inputs-Outputs: An Interdisciplinary Conference on Engagement in HCI and Performance. ACM: New York.  Article 1.  DOI: 10.1145/2557595.2557596 Download it here
  • Witchel HJ, Lavia L, Westling C, Healy A, Needham R, Chockalingam N (2013). Using body language indicators for assessing the effects of soundscape quality on individuals. AIA-DAGA Conference on Acoustics (Merano). Download it here

2012

  • Witchel HJ, Healy A, Needham R, Westling C, Chockalingam N (2012). Comparing four technologies for measuring postural micromovements during monitor engagement. ECCE 2012 Proceedings of the 30th European Conference on Cognitive Ergonomics. 189-192. Download it here
  • Lavia L, Easteal M, Close D, Witchel HJ, Axelsson O, Ware M, Dixon M. Sounding Brighton: practical approaches towards better Soundscapes. Internoise 2012 (New York). Download it here

2011

  • Laughlin Z, Conreen M, Witchel HJ, and Miodownik M (2011). The use of standard electrode potentials to predict the taste of solid metals. Food Quality and Preference, 22(7): 628-637. Download it here
  • Adeniran I, McPate MJ, Witchel HJ, Hancox JC, Zhang H (2011). Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome. PLoS Comput Biol. 7(12):e1002313.  Download it here
  • Möller C, Witchel H (2011). Automated electrophysiology makes the pace for cardiac ion channel safety screening. Front Pharmacol. 2:73.  Download it here

2010

  • Witchel HJ (2010). Drug-induced hERG block and long QT syndrome. Cardiovasc. Therapeu., 29(4):251-9.
  • Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC (2010). Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. J Pharmacol Toxicol Methods 61(2):178-91.
  • Witchel HJ (2010). Emerging trends in ion channel-based assays for predicting the cardiac safety of drugs. Investigative Drugs 13(2):90-6.

2009

  • McPate MJ, Zhang H, Cordeiro JM, Dempsey CE, Witchel HJ, Hancox JC (2009). hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome. Biochem Biophys Res Commun. 386(1):111-7.
  • McPate MJ, Zhang H, Adeniran I, Cordeiro JM, Witchel HJ, Hancox JC (2009). Comparative effects of the short QT N588K mutation at 37°C on hERG K+ channel current during ventricular, purkinje fibre and atrial action potentials: an action potential clamp study. J. Pharm. Pharmacol., 60(1):23-41.

2008

  • McPate MJ, Duncan RS, Hancox JC, Witchel HJ (2008). Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br. J. Pharmacol., 155(6):957-66.

2007

  • Belsey MJ, Davies AR, Witchel HJ, Kozlowski RZ (2007). Inhibition of ERK and JNK Decreases Both Osmosensitive Taurine Release and Cell Proliferation in Glioma Cells. Neurochem. Res., 32(11):1940-9.
  • Witchel HJ (2007). The hERG potassium channel as therapeutic target. Expert Opin. Ther. Targets, 11(3):321-36.
  • Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC (2007) Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin. Biochem. Pharmacol., 74(3):425-37.

2006

  • Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC (2006). hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656. Biochem Biophys Res Commun. 351(1):273-80.
  • Davies SJ, Hood SD, Argyropoulos SV, Morris K, Bell C, Witchel HJ, Jackson PR, Nutt DJ, Potokar JP (2006) Depleting serotonin enhances both cardiovascular and psychological stress reactivity in recovered patients with anxiety disorders. J Clin Psychopharmacol. 26(4): 414-8
  • McPate MJ, Duncan RS, Witchel HJ, Hancox JC (2006). Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome. J. Mol. Cell. Cardiol. 41 (3): 563-6.
  • The above manuscript was highlighted in the journal by an accompanying editorial/commentary: Dumaine R and Antzelevitch C (2006). Disopyramide: although potentially life-threatening in the setting oflong QT, could it be life-saving in short QT syndrome. J. Mol. Cell. Cardiol., 41(3): 421-3.
  • McPate MJ, Witchel HJ, Hancox JC (2006). Short QT syndrome. Future Cardiology, 2(3): 293-301.
  • Ridley JM, Milnes JT, Witchel HJ, Hancox JC (2006). Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. FEBS Lett., 580(8):1999-2005.
  • Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL. (2006). Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br. J. Pharmacol., 147(8):905-16.
  • Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ (2006). Erythromycin block of the HERG K+ channel: Accessibility to F656 and Y652. Biochem. Biophys. Res. Commun. 341(2):500-6.
  • Ridley JM, Milnes JT, Hancox JC, Witchel HJ (2006). Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel. J. Mol. Cell. Cardiol., 40(1):107-118.

2005

  • Mitcheson JS, Perry M, Stansfeld P, Sanguinetti MC, Witchel HJ and Hancox JC (2005). Structural determinants for high affinity block of hERG potassium channels. In The hERG Potassium channel: structure, function and long QT syndrome, pp. 136-149. DJ Chadwick and J Goode (eds.). Novartis Foundation Symposium 266. John Wiley and Sons: Chichester (UK).
  • McPate MJ, Duncan RS, Milnes JT, Witchel HJ, Hancox JC (2005). The N588K-HERG K+ channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37ºC. Biochem. Biophys. Res. Commun., 334(2):441-449.

2004

  • Ridley JM, Milnes JT, Witchel HJ, Hancox JC (2004). High affinity HERG K+ channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656. Biochem. Biophys. Res. Commun., 325(3):883-91.
  • Finlayson K, Witchel HJ, McCulloch J, Sharkey J (2004). Acquired QT interval prolongation and HERG: implications for drug discovery and development. Eur. J. Pharmacol. 500(1-3): 129-42.
  • Argyropoulos SV, Hood SD, Adrover M, Bell CJ, Rich AS, Nash JR, Rich NC, Witchel HJ, Nutt DJ (2004). Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder. Biol. Psychiatry, 56(7): 503-509.
  • Witchel HJ, Dempsey CE, Sessions RB, Perry M, Milnes JT, Hancox JC, Mitcheson JS (2004). The low potency, voltage-dependent HERG blocker propafenone – molecular determinants and drug trapping. Mol. Pharmacol. 66(5):1201-12.
  • Miller AL, Witchel HJ, Hancox JC, Jeremy JY, Jackson CL, Plane F (2004). Moderately Elevated Plasma Homocysteine Impairs Functional Endothelial Recovery Following Denudation of Mouse Carotid Arteries. Metabolism, 53(6): 760-5.
  • Ridley JM, Dooley PC, Milnes JT, Witchel HJ, Hancox JC (2004). Lidoflazine is a high affinity blocker of the HERG K+ channel. J. Mol. Cell. Cardiol., 36(5): 701-5.
  • Yuill KH, Borg JJ, Ridley JM, Milnes JT, Witchel HJ, Paul AA, Kozlowski RZ, Hancox JC (2004). Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene – without QT interval prolongation. Biochem. Biophys. Res. Commun., 318(2): 556-61.
  • Lastraioli E, Guasti L, Crociani O, Polvani S, Hofmann G, Witchel H, Bencini L, Calistri M, Messerini L, Scatizzi M, Moretti R, Wanke E, Olivotto M, Mugnai G, and Arcangeli A (2004). herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res., 64(2): 606-611.

2003

  • Milnes JT, Crociani O, Arcangeli A, Hancox JC and Witchel HJ (2003). Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Brit. J. Pharmacol., 139(5): 887-898.
  • Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, and Witchel HJ (2003). Preferential closed channel blockade of HERG potassium currents by chemically synthesized BeKm-1 scorpion toxin. FEBS Lett., 547: 20-26.
  • Belsey MJ, Culliford SJ, Morley RM, Witchel HJ and Kozlowski RZ (2003). Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression. Eur. J. Pharmacol., 474(2-3): 185-193.
  • Witchel HJ, Milnes JT, Mitcheson JS and Hancox JC (2003). Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. J. Pharmacol. Toxicol Methods, 48(2): 65-80.
  • The above manuscript was highlighted in the journal by an accompanying editorial/commentary: Mitcheson JS (2003). Drug binding to HERG channels: evidence for a ‘non-aromatic’ site for fluvoxamine. Brit. J. Pharmacol., 139: 883-884.
  • Ridley JM, Milnes JT, Benest AV, Masters, JD, Witchel HJ, Hancox JC (2003). Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide. Biochem. Biophys. Res. Commun., 306(2): 388-393.
  • Ridley JM, Milnes JT, Zhang YH, Witchel HJ, Hancox JC (2003). Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine. J. Physiol., 549.3: 667-672.
  • Witchel HJ, Hancox JC, Nutt DJ and Wilson S (2003). Antipsychotics, HERG and sudden death. Brit. J. Psychiatry, 182: 171-172.
  • Witchel HJ, Hancox JC and Nutt DJ (2003). Psychotropic drugs, cardiac arrhythmia and sudden death. J. Clin. Psychopharmacol., 23(1): 58-77.

2002

  • Paul AA, Witchel HJ and Hancox JC (2002). Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine. Brit. J. Pharmacol., 136: 717-29.
  • Witchel HJ, Pabbathi VK, Hofmann G, Paul AA and Hancox JC (2002). Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett., 512:59-66.

2001

  • Paul AA, Leishman DJ, Witchel HJ and Hancox JC (2001). Effects of the class III antiarrhythmic agent dofetilide (uk-38,798) on 1-type calcium current from rabbit ventricular myocytes. J. Pharm. Pharmacol.. 53:1671-1678.
  • Paul AA, Witchel HJ and Hancox JC (2001). Inhibition of HERG potassium channel current by the Class Ia antiarrhythmic agent disopyramide. Biochem. Biophys. Res. Commun., 280:1243-1250.

2000

  • Witchel HJ and Hancox JC (2000). Familial and acquired Long QT Syndrome and the cardiac rapid delayed rectifier potassium current. Clin. Exp. Pharmacol. Physiol., 27:753-766.
  • Hancox JC and Witchel HJ (2000). Psychotropic drugs, HERG, and the heart. Lancet 356: 428.

1999

  • Teschemacher AG, Seward EP, Hancox JC and Witchel HJ (1999). Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. Brit. J. Pharmacol., 128:479-485.

1998

  • Hancox JC, Witchel HJ and Varghese A (1998). Alteration of HERG current profile during the cardiac ventricular action potential, following a pore mutation. Biochem. Biophys. Res. Commun., 253:719-24.
  • Hancox JC, Levi AJ and Witchel HJ (1998). Time course and voltage dependence of expressed HERG current compared with native ‘rapid’ delayed rectifier K current during the cardiac ventricular action potential. Eur. J. Physiol. Pflügers Archiv, 436:843-853.